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Hypoxic upregulation of preproendothelin-1 gene expression is associated with protein tyrosine kinase-PI3K signaling in cultured lung vascular endothelial cells

Hypoxia-increased endothelin-1 (ET-1) expression contributes to vasoconstriction and vessel wall thickening, often seen in the progression of pulmonary hypertension. We sought to investigate whether hypoxic modulation of preproET-1 transcription is associated with protein tyrosine kinase and phospha...

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Autors principals: Zhang, Jianliang, Narayan, Vikram M., Juedes, Noah, Patel, Jawaharlal M.
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680048/
https://ncbi.nlm.nih.gov/pubmed/19436835
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