Stereoselective Formation of a Functionalized Dipeptide Isostere by Zinc Carbenoid-mediated Chain Extension

[Image: see text] The application of a zinc carbenoid-mediated chain extension reaction to a functionalized peptide isostere is reported. The cleavage site of human CVM protease was utilized as a target for testing the synthetic methodology. The utility of this chain extension reaction is demonstrat...

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Main Authors: Lin, Weimin, Theberge, Cory R., Henderson, Timothy J., Zercher, Charles K., Jasinski, Jerry, Butcher, Ray J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680025/
https://ncbi.nlm.nih.gov/pubmed/19055379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo801993k
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