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Oxidative and Excitatory Mechanisms of Developmental Neurotoxicity: Transcriptional Profiles for Chlorpyrifos, Diazinon, Dieldrin, and Divalent Nickel in PC12 Cells

BACKGROUND: Oxidative stress and excitotoxicity underlie the developmental neurotoxicity of numerous chemicals. OBJECTIVES: We compared the effects of organophosphates (chlorpyrifos and diazinon), an organo-chlorine (dieldrin), and a metal [divalent nickel (Ni(2+))] to determine how these mechanisms...

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Detalhes bibliográficos
Main Authors: Slotkin, Theodore A., Seidler, Frederic J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679603/
https://ncbi.nlm.nih.gov/pubmed/19440498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0800251
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