Inhibition of Sphingosine Kinase by Bovine Viral Diarrhea Virus NS3 Is Crucial for Efficient Viral Replication and Cytopathogenesis

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid implicated in diverse cellular functions including survival, proliferation, tumorigenesis, inflammation, and immunity. Sphingosine kinase (SphK) contributes to these functions by converting sphingosine to S1P. We report here that the nonstruc...

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Autores principales: Yamane, Daisuke, Zahoor, Muhammad A., Mohamed, Yassir M., Azab, Walid, Kato, Kentaro, Tohya, Yukinobu, Akashi, Hiroomi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679466/
https://ncbi.nlm.nih.gov/pubmed/19293152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807498200
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