Genetic instability caused by loss of MutS homolog 3 in human colorectal cancer

Microsatellite instability (MSI) is a hallmark of mismatch repair deficiency. High levels of MSI at mono- and dinucleotide repeats in colorectal cancer (CRC) are attributed to inactivation of the mismatch repair genes, hMLH1 and hMSH2. CRC with low levels of MSI (MSI-L) exists; however its molecular...

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Hauptverfasser: Haugen, Astrid C., Goel, Ajay, Yamada, Kanae, Marra, Giancarlo, Nguyen, Thuy-Phuong, Nagasaka, Takeshi, Kanazawa, Shinsaku, Koike, Junichi, Kikuchi, Yoshinori, Zhong, Xiaoling, Arita, Michitsune, Shibuya, Kazutoshi, Oshimura, Mitsuo, Hemmi, Hiromichi, Boland, Clement Richard, Koi, Minoru
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678948/
https://ncbi.nlm.nih.gov/pubmed/18922920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0002
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