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Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity

Conjugation of gonadotropin-releasing hormone (GnRH) analogues GnRH-III, MI-1544, and MI-1892 through lysyl side chains and a tetrapeptide spacer, Gly-Phe-Leu-Gly (X) to a copolymer, poly(N-vinylpyrrolidone-co-maleic acid) (P) caused increased antiproliferative activity toward MCF-7 and MDA-MB-231 b...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Pályi, I., Vincze, B., Lovas, S., Mező, I., Pató, J., Kálnay, A., Turi, G., Gaál, D., Mihalik, R., Péter, I., Teplán, I., Murphy, R. F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1999
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26789/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051647/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2361
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