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A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function
Aurora kinase-A and -B are key regulators of the cell cycle and tumorigenesis. It has remained a mystery why these 2 Aurora kinases, although highly similar in protein sequence and structure, are distinct in subcellular localization and function. Here, we report the striking finding that a single am...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678431/ https://ncbi.nlm.nih.gov/pubmed/19357306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900833106 |
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