Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells

Epithelial (E)-cadherin and its associated cytoplasmic proteins (α-, β-, and γ-catenins) are important mediators of epithelial cell–cell adhesion and intracellular signaling. Much evidence exists suggesting a tumor/invasion suppressor role for E-cadherin, and loss of expression, as well as mutations...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Efstathiou, J. A., Liu, D., Wheeler, J. M. D., Kim, H. C., Beck, N. E., Ilyas, M., Karayiannakis, A. J., Mortensen, N. J. McC., Kmiot, W., Playford, R. J., Pignatelli, M., Bodmer, W. F.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26781/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051639/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2316
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