DNA-MVA Vaccine Protection after X4 SHIV Challenge in Macaques Correlates with Day-of-Challenge Antiviral CD4(+) Cell-Mediated Immunity Levels and Postchallenge Preservation of CD4(+) T Cell Memory

The ability of vaccines to induce immunity both in mucosal and systemic compartments may be required for prevention of HIV infection and AIDS. We compared DNA-MVA vaccination regimens adjuvanted by IL-12 DNA, administered intramuscularly and nasally or only nasally. Most of the vaccinated Rhesus mac...

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Autores principales: MANRIQUE, MARIANA, MICEWICZ, EWA, KOZLOWSKI, PAMELA A., WANG, SHAINN-WEI, AURORA, DEEPTI, WILSON, ROBERT L., GHEBREMICHAEL, MUSIE, MAZZARA, GAIL, MONTEFIORI, DAVID, CARVILLE, ANGELA, MANSFIELD, KEITH G., ALDOVINI, ANNA
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677999/
https://ncbi.nlm.nih.gov/pubmed/18373436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2007.0191
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