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Inhibition of GSK-3β promotes survival and proliferation of megakaryocytic cells through a β-catenin-independent pathway

The interaction of thrombopoietin (TPO) with its receptor c-Mpl initiates intracellular signals that are critical for megakaryopoiesis. Previously we and others have shown that TPO activates PI3K and Akt and that this pathway is important for megakaryocyte growth. Here, we investigate the importance...

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Hlavní autoři: Soda, Mie, Willert, Karl, Kaushansky, Kenneth, Geddis, Amy E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677808/
https://ncbi.nlm.nih.gov/pubmed/18804163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.09.001
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