Pivotal Role of the α(2A)-Adrenoceptor in Producing Inflammation and Organ Injury in a Rat Model of Sepsis

BACKGROUND: Norepinephrine (NE) modulates the responsiveness of macrophages to proinflammatory stimuli through the activation of adrenergic receptors (ARs). Being part of the stress response, early increases of NE in sepsis sustain adverse systemic inflammatory responses. The intestine is an importa...

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Detalhes bibliográficos
Main Authors: Miksa, Michael, Das, Padmalaya, Zhou, Mian, Wu, Rongqian, Dong, Weifeng, Ji, Youxin, Goyert, Sanna M., Ravikumar, Thanjavur S., Wang, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2677660/
https://ncbi.nlm.nih.gov/pubmed/19430535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005504
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