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Targeting the MDM2-p53 Interaction for Cancer Therapy

p53 is a powerful tumor suppressor and is an attractive cancer therapeutic target because it can be functionally activated to eradicate tumors. The gene encoding p53 protein is mutated or deleted in half of human cancers, which inactivates its tumor suppressor activity. In the remaining cancers with...

詳細記述

保存先:
書誌詳細
主要な著者: Shangary, Sanjeev, Wang, Shaomeng
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676446/
https://ncbi.nlm.nih.gov/pubmed/18765522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-5136
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