Erythrocyte Hemolysis and Hemoglobin Oxidation Promote Ferric Chloride-induced Vascular Injury

The release of redox-active iron and heme into the blood-stream is toxic to the vasculature, contributing to the development of vascular diseases. How iron induces endothelial injury remains ill defined. To investigate this, we developed a novel ex vivo perfusion chamber that enables direct analysis...

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Bibliographic Details
Main Authors: Woollard, Kevin J., Sturgeon, Sharelle, Chin-Dusting, Jaye P. F., Salem, Hatem H., Jackson, Shaun P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676043/
https://ncbi.nlm.nih.gov/pubmed/19276082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809095200
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