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IKKβ Mediates Cell Shape-Induced Aromatase Expression and Estrogen Biosynthesis in Adipose Stromal Cells

Aromatase (Cyp19) is a key enzyme in estrogen biosynthesis and an important target in breast cancer therapy. Within tumor microenvironment, tumor cells stimulate aromatase expression in adipose stromal cells (ASCs), which in turn promotes estrogen-dependent growth of estrogen receptor (ER)-positive...

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Autori principali: Ghosh, Sagar, Choudary, Ahsan, Ghosh, Sangeeta, Musi, Nicolas, Hu, Yanfen, Li, Rong
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Endocrine Society 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675949/
https://ncbi.nlm.nih.gov/pubmed/19221050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0468
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