Faciogenital Dysplasia Protein (FGD1) Regulates Export of Cargo Proteins from the Golgi Complex via Cdc42 Activation

Mutations in the FGD1 gene are responsible for the X-linked disorder known as faciogenital dysplasia (FGDY). FGD1 encodes a guanine nucleotide exchange factor that specifically activates the GTPase Cdc42. In turn, Cdc42 is an important regulator of membrane trafficking, although little is known abou...

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Main Authors: Egorov, Mikhail V., Capestrano, Mariagrazia, Vorontsova, Olesya A., Di Pentima, Alessio, Egorova, Anastasia V., Mariggiò, Stefania, Ayala, M. Inmaculada, Tetè, Stefano, Gorski, Jerome L., Luini, Alberto, Buccione, Roberto, Polishchuk, Roman S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675621/
https://ncbi.nlm.nih.gov/pubmed/19261807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-11-1136
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