Analysis of T cell receptor Vβ diversity in peripheral CD4(+) and CD8(+) T lymphocytes in patients with autoimmune thyroid diseases

Autoimmune thyroid diseases are characterized by intrathyroidal infiltration of CD4(+) and CD8(+) T lymphocytes reactive to self-thyroid antigens. Early studies analysing T cell receptor (TCR) Vα gene usage have shown oligoclonal expansion of intrathyroidal T lymphocytes but not peripheral blood T c...

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Main Authors: Okajima, M, Wada, T, Nishida, M, Yokoyama, T, Nakayama, Y, Hashida, Y, Shibata, F, Tone, Y, Ishizaki, A, Shimizu, M, Saito, T, Ohta, K, Toma, T, Yachie, A
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2009
Teme:
Translational Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675246/
https://ncbi.nlm.nih.gov/pubmed/19040601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03842.x
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