A pharmacokinetic evaluation of five H(1) antagonists after an oral and intravenous microdose to human subjects

AIMS: To evaluate the pharmacokinetics (PK) of five H(1) receptor antagonists in human volunteers after a single oral and intravenous (i.v.) microdose (0.1 mg). METHODS: Five H(1) receptor antagonists, namely NBI-1, NBI-2, NBI-3, NBI-4 and diphenhydramine, were administered to human volunteers as a...

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Detalhes bibliográficos
Main Authors: Madan, Ajay, O'Brien, Zhihong, Wen, Jianyun, O'Brien, Chris, Farber, Robert H, Beaton, Graham, Crowe, Paul, Oosterhuis, Berend, Garner, R Colin, Lappin, Graham, Bozigian, Haig P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675039/
https://ncbi.nlm.nih.gov/pubmed/19523012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03351.x
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