T cell sensitivity to TGF-β is required for the effector function but not the generation of splenic CD8(+) regulatory T cells induced via the injection of antigen into the anterior chamber

The introduction of antigen into the anterior chamber (AC) of the eye induces the production of antigen-specific splenic CD8(+) regulatory T cells (AC-SPL cells) that suppress a delayed-type hypersensitivity (DTH) reaction in immunized mice. Because the generation of these regulatory T cells is also...

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Main Authors: Cone, Robert E., Chattopadhyay, Subhasis, Sharafieh, Roshanak, Lemire, Yen, O'Rourke, James, Flavell, Richard A., Clark, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2675031/
https://ncbi.nlm.nih.gov/pubmed/19325036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxp023
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