In vivo (1)H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

BACKGROUND: Donepezil improves cognitive functions in AD patients. Effects on the brain metabolites N-acetyl-L-aspartate, choline and myo-inositol levels have been reported in clinical studies using this drug. The APP/PS1 mouse coexpresses the mutated forms of human β-amyloid precursor protein (APP)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Westman, Eric, Spenger, Christian, Öberg, Johanna, Reyer, Henry, Pahnke, Jens, Wahlund, Lars-Olof
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2009
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674598/
https://ncbi.nlm.nih.gov/pubmed/19351388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-10-33
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