Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice

BACKGROUND: Obsessive compulsive disorder (OCD) is characterized by intrusive thoughts, images, or impulses and/or repetitive stereotypical behavior. OCD patients exhibit reduced prepulse inhibition (PPI), and symptom exacerbation following challenge with 5-HT1B receptor agonists. Recently, gain-of-...

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Detalhes bibliográficos
Main Authors: Shanahan, Nancy A., Holick, Kerri A., Masten, Virginia L., Waeber, Christian, Ansorge, Mark, Gingrich, Jay A., Geyer, Mark A., Hen, Rene, Dulawa, Stephanie C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674010/
https://ncbi.nlm.nih.gov/pubmed/19013555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2008.09.026
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