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Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B

The oncogene p3k, coding for a constitutively active form of phosphatidylinositol 3-kinase (PI 3-kinase), strongly activates myogenic differentiation. Inhibition of endogenous PI 3-kinase activity with the specific inhibitor LY294002, or with dominant-negative mutants of PI 3-kinase, interferes with...

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Bibliografiske detaljer
Main Authors: Jiang, Bing-Hua, Aoki, Masahiro, Zheng, Jenny Z., Li, Jian, Vogt, Peter K.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC26739/
https://ncbi.nlm.nih.gov/pubmed/10051597
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