A homeostatic model of IκB metabolism to control constitutive NF-κB activity

Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease-associated aberrant activity of the pathway is often due to misregulation of the equilibrium state. The transcription factor NF-κB is typically described as being held inactiv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: O'Dea, Ellen L, Barken, Derren, Peralta, Raechel Q, Tran, Kim T, Werner, Shannon L, Kearns, Jeffrey D, Levchenko, Andre, Hoffmann, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673708/
https://ncbi.nlm.nih.gov/pubmed/17486138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb4100148
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