Customized Treatment in Non-Small-Cell Lung Cancer Based on EGFR Mutations and BRCA1 mRNA Expression

BACKGROUND: Median survival is 10 months and 2-year survival is 20% in metastatic non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy. A small fraction of non-squamous cell lung cancers harbor EGFR mutations, with improved outcome to gefitinib and erlotinib. Experimental evid...

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Main Authors: Rosell, Rafael, Perez-Roca, Laia, Sanchez, Jose Javier, Cobo, Manuel, Moran, Teresa, Chaib, Imane, Provencio, Mariano, Domine, Manuel, Sala, Maria Angeles, Jimenez, Ulpiano, Diz, Pilar, Barneto, Isidoro, Macias, Jose Antonio, de las Peñas, Ramon, Catot, Silvia, Isla, Dolores, Sanchez, Jose Miguel, Ibeas, Rafael, Lopez-Vivanco, Guillermo, Oramas, Juana, Mendez, Pedro, Reguart, Noemi, Blanco, Remei, Taron, Miquel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673583/
https://ncbi.nlm.nih.gov/pubmed/19415121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005133
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