VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death

Frontotemporal lobar degeneration (FTLD) with inclusion body myopathy and Paget disease of bone is a rare, autosomal dominant disorder caused by mutations in the VCP (valosin-containing protein) gene. The disease is characterized neuropathologically by frontal and temporal lobar atrophy, neuron loss...

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Bibliographische Detailangaben
Hauptverfasser: Gitcho, Michael A., Strider, Jeffrey, Carter, Deborah, Taylor-Reinwald, Lisa, Forman, Mark S., Goate, Alison M., Cairns, Nigel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673306/
https://ncbi.nlm.nih.gov/pubmed/19237541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900992200
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