Neurofibromin regulation of ERK signaling modulates GABA release and learning

We uncovered a new role for ERK signaling in GABA release, long-term potentiation (LTP) and learning, and show that disruption of this mechanism accounts for the learning deficits in a mouse model for Neurofibromatosis type I (NF1), a common genetic cause for learning disabilities. Genetic, pharmaco...

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Autors principals: Cui, Yijun, Costa, Rui M, Murphy, Geoffrey G, Elgersma, Ype, Zhu, Yuan, Gutmann, David H., Parada, Luis F., Mody, Istvan, Silva, Alcino J
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673196/
https://ncbi.nlm.nih.gov/pubmed/18984165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.060
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