Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability

The molecular mechanisms of endothelial nitric oxide synthase (eNOS) regulation of microvascular permeability remain unresolved. Agonist-induced internalization may have a role in this process. We demonstrate here that internalization of eNOS is required to deliver NO to subcellular locations to inc...

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Autors principals: Sánchez, Fabiola A., Rana, Roshniben, Kim, David D., Iwahashi, Toru, Zheng, Ruifang, Lal, Brajesh K., Gordon, Donna M., Meininger, Cynthia J., Durán, Walter N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672508/
https://ncbi.nlm.nih.gov/pubmed/19342481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812694106
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