Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

T-tubular invaginations of the sarcolemma of ventricular cardiomyocytes contain junctional structures functionally coupling L-type calcium channels to the sarcoplasmic reticulum calcium-release channels (the ryanodine receptors), and therefore their configuration controls the gain of calcium-induced...

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Hlavní autoři: Lyon, Alexander R., MacLeod, Ken T., Zhang, Yanjun, Garcia, Edwin, Kanda, Gaelle Kikonda, Lab, Max J., Korchev, Yuri E., Harding, Sian E., Gorelik, Julia
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672472/
https://ncbi.nlm.nih.gov/pubmed/19342485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809777106
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