Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells

PURPOSE: Oxidative stress is a risk factor for the onset and progression of primary open-angle glaucoma (POAG), but the exact molecular basis remains unknown. Here, we investigated the mechanisms for Pro370Leu mutant myocilin to induce mitochondrial dysfunction and subsequent reactive oxygen species...

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Bibliografske podrobnosti
Main Authors: He, Yuan, Leung, Kar Wah, Zhuo, Ye-Hong, Ge, Jian
Format: Artigo
Jezik:Inglês
Izdano: Molecular Vision 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2672150/
https://ncbi.nlm.nih.gov/pubmed/19390644
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