The Plasticity of Oncogene Addiction: Implications for Targeted Therapies Directed to Receptor Tyrosine Kinases

A common mutation of the epidermal growth factor receptor (EGFR) in glioblastoma multiforme (GBM) is an extracellular truncation known as the de2-7 EGFR (or EGFRvIII). Hepatocyte growth factor (HGF) is the ligand for the receptor tyrosine kinase (RTK) c-Met, and this signaling axis is often active i...

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Detalhes bibliográficos
Main Authors: Pillay, Vinochani, Allaf, Layal, Wilding, Alexander L, Donoghue, Jacqui F, Court, Naomi W, Greenall, Steve A, Scott, Andrew M, Johns, Terrance G
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671857/
https://ncbi.nlm.nih.gov/pubmed/19412429
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