Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung Maturation

Cyld encodes a 956-amino acid deubiquitinating enzyme (CYLD), which is a negative regulator of nuclear factor κB and mitogen-activated protein kinase pathways. Mutations that truncate and inactivate the carboxyl-terminal deubiquitinating domain of CYLD underlie the development of skin appendage tumo...

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Main Authors: Trompouki, Eirini, Tsagaratou, Ageliki, Kosmidis, Stylianos K, Dollé, Pascal, Qian, Jun, Kontoyiannis, Dimitris L, Cardoso, Wellington V, Mosialos, George
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2009
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671692/
https://ncbi.nlm.nih.gov/pubmed/19412431
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