Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

Signaling factors involved in CNS development have been used to control the differentiation of embryonic stem cells (ESCs) into mesencephalic dopamine (mesDA) neurons, but tend to generate a limited yield of desired cell type. Here we show that forced expression of Lmx1a, a transcription factor func...

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Detalhes bibliográficos
Main Authors: Friling, Stina, Andersson, Elisabet, Thompson, Lachlan H., Jönsson, Marie E., Hebsgaard, Josephine B., Nanou, Evanthia, Alekseenko, Zhanna, Marklund, Ulrika, Kjellander, Susanna, Volakakis, Nikolaos, Hovatta, Outi, El Manira, Abdeljabbar, Björklund, Anders, Perlmann, Thomas, Ericson, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671325/
https://ncbi.nlm.nih.gov/pubmed/19383789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902396106
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