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Development of a novel mouse glioma model using lentiviral vectors
We report the development of a new method to induce glioblastoma multiforme in adult immunocompetent mice by injecting Cre-loxP–controlled lentiviral vectors expressing oncogenes. Cell type- or region-specific expression of activated forms of the oncoproteins Harvey-Ras and AKT in fewer than 60 glia...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671237/ https://ncbi.nlm.nih.gov/pubmed/19122659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1863 |
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