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Challenges to the Therapeutic Pipeline for Irritable Bowel Syndrome: Endpoints and Regulatory Hurdles

Recent advances in our understanding of basic neuroenteric mechanisms and the role of effectors and transmitters in the brain-gut axis have provided opportunities to develop new therapeutic agents for irritable bowel syndrome (IBS). Furthermore, human pharmacodynamic studies utilizing transit, colon...

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Detalhes bibliográficos
Main Authors: Camilleri, Michael, Chang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671226/
https://ncbi.nlm.nih.gov/pubmed/18848833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.09.005
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