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The fast-folding HP35 double mutant has a substantially reduced primary folding free energy barrier
The LYS24∕29NLE double mutant of villin headpiece subdomain (HP35) is the fastest folding protein known so far with a folding time constant of 0.6 μs. In this work, the folding mechanism of the mutant has been investigated by both conventional and replica exchange molecular dynamics (CMD and REMD) s...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Institute of Physics
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671186/ https://ncbi.nlm.nih.gov/pubmed/19045234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.2995987 |
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