Antitumor Activity and Mechanism of Action of the Cyclopenta[b]benzofuran, Silvestrol

BACKGROUND: Flavaglines are a family of natural products from the genus Aglaia that exhibit anti-cancer activity in vitro and in vivo and inhibit translation initiation. They have been shown to modulate the activity of eIF4A, the DEAD-box RNA helicase subunit of the eukaryotic initiation factor (eIF...

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Detalhes bibliográficos
Main Authors: Cencic, Regina, Carrier, Marilyn, Galicia-Vázquez, Gabriela, Bordeleau, Marie-Eve, Sukarieh, Rami, Bourdeau, Annie, Brem, Brigitte, Teodoro, Jose G., Greger, Harald, Tremblay, Michel L., Porco, John A., Pelletier, Jerry
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671147/
https://ncbi.nlm.nih.gov/pubmed/19401772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005223
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