Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

Long-term potentiation (LTP) is accompanied by dendritic spine growth and changes in the composition of the postsynaptic density (PSD). We find that activity-dependent growth of apical spines of CA1 pyramidal neurons is accompanied by destabilization of the PSD that results in transient loss and rap...

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Главные авторы: Steiner, Pascal, Higley, Michael J., Xu, Weifeng, Czervionke, Brian L., Malenka, Robert C., Sabatini, Bernardo L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671083/
https://ncbi.nlm.nih.gov/pubmed/19081375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.10.014
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