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CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy
We report the discovery of a new prodrug, 6-chloro-9-nitro-5-oxo-5Hbenzo[a]phenoxazine (CNOB). This prodrug is efficiently activated by ChrR6, the highly active prodrug activating bacterial enzyme we have previously developed. The CNOB/ChrR6 therapy was effective in killing several cancer cell lines...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670992/ https://ncbi.nlm.nih.gov/pubmed/19190118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0707 |
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