N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes

BACKGROUND: While doxorubicin (DOX) is widely used in cancer chemotherapy, long-term severe cardiotoxicity limits its use. This is the first report of the chemoprotective efficacy of a relatively new thiol antioxidant, N-acetylcysteine amide (NACA), on DOX-induced cell death in cardiomyocytes. We hy...

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Main Authors: Shi, Rong, Huang, Chuan-Chin, Aronstam, Robert S, Ercal, Nuran, Martin, Adam, Huang, Yue-Wern
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670828/
https://ncbi.nlm.nih.gov/pubmed/19368719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-9-7
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