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Application of Homozygosity Haplotype Analysis to Genetic Mapping with High-Density SNP Genotype Data
BACKGROUND: In families segregating a monogenic genetic disorder with a single disease gene introduction, patients share a mutation-carrying chromosomal interval with identity-by-descent (IBD). Such a shared chromosomal interval or haplotype, surrounding the actual pathogenic mutation, is typically...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670504/ https://ncbi.nlm.nih.gov/pubmed/19399176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005280 |
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