Application of Homozygosity Haplotype Analysis to Genetic Mapping with High-Density SNP Genotype Data

BACKGROUND: In families segregating a monogenic genetic disorder with a single disease gene introduction, patients share a mutation-carrying chromosomal interval with identity-by-descent (IBD). Such a shared chromosomal interval or haplotype, surrounding the actual pathogenic mutation, is typically...

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Hlavní autoři: Jiang, Haiyan, Orr, Andrew, Guernsey, Duane L., Robitaille, Johane, Asselin, Géraldine, Samuels, Mark E., Dubé, Marie-Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670504/
https://ncbi.nlm.nih.gov/pubmed/19399176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005280
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