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The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests

BACKGROUND AND OBJECTIVES: Clinical trials increasingly use results of diagnostic tests as surrogate outcomes. Our objective was to answer the following questions: (1) is the parameter measured by the reference standard a valid surrogate? (2) How does the tests accuracy influence the estimate of the...

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Main Authors: Kassaï, Behrouz, Shah, Nirav R., Leizorovicza, Alain, Cucherat, Michel, Gueyffier, Francois, Boissel, Jean-Pierre
פורמט: Artigo
שפה:Inglês
יצא לאור: 2005
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670365/
https://ncbi.nlm.nih.gov/pubmed/16168350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jclinepi.2005.02.024
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