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The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests
BACKGROUND AND OBJECTIVES: Clinical trials increasingly use results of diagnostic tests as surrogate outcomes. Our objective was to answer the following questions: (1) is the parameter measured by the reference standard a valid surrogate? (2) How does the tests accuracy influence the estimate of the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670365/ https://ncbi.nlm.nih.gov/pubmed/16168350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jclinepi.2005.02.024 |
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