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Synthesis of P,N-Heterocycles from ω-Amino-H-Phosphinates: Conformationally Restricted α-Amino Acid Analogs

P,N-Heterocycles (3-hydroxy-1,3-azaphospholane and 3-hydroxy-1,3-azaphosphorinane-3-oxide) are synthesized in moderate yield from readily available ω-amino-H-phosphinates and aldehydes or ketones via an intramolecular Kabachnik-Fields reaction. The products are conformationally restricted phosphinic...

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Detalhes bibliográficos
Main Authors: Queffelec, Clémence, Ribière, Patrice, Montchamp, Jean-Luc
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670240/
https://ncbi.nlm.nih.gov/pubmed/18855477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo801768y
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