Loss of integrin α(v)β(8) on dendritic cells causes autoimmunity and colitis in mice

The cytokine transforming growth factor-β (TGF-β) is an important negative regulator of adaptive immunity1–3. TGF-β is secreted by cells as an inactive precursor that must be activated to exert biological effects4, but the mechanisms that regulate TGF-β activation and function in the immune system a...

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Autores principales: Travis, Mark A., Reizis, Boris, Melton, Andrew C., Masteller, Emma, Tang, Qizhi, Proctor, John M., Wang, Yanli, Bernstein, Xin, Huang, Xiaozhu, Reichardt, Louis F., Bluestone, Jeffrey A., Sheppard, Dean
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670239/
https://ncbi.nlm.nih.gov/pubmed/17694047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06110
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