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Agonist- and antagonist-induced conformational changes of loop F and their contributions to the ρ1 GABA receptor function
Binding of γ-aminobutyric acid (GABA) to its receptor initiates a conformational change to open the channel, but the mechanism of the channel activation is not well understood. To this end, we scanned loop F (K210–F227) in the N-terminal domain of the ρ1 GABA receptor expressed in Xenopus oocytes us...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670029/ https://ncbi.nlm.nih.gov/pubmed/19015197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.160093 |
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