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Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional

An understanding of nuclear reprogramming is fundamental to the use of cells in regenerative medicine. Due to technological obstacles, the time course and extent of reprogramming of cells following fusion has not been assessed to date. Here, we show that hundreds of genes are activated or repressed...

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Detalhes bibliográficos
Main Authors: Palermo, Adam, Doyonnas, Regis, Bhutani, Nidhi, Pomerantz, Jason, Alkan, Ozan, Blau, Helen M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669427/
https://ncbi.nlm.nih.gov/pubmed/19141533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-122903
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