Defective Hepatitis B Virus DNA Is Not Associated with Disease Status But Is Reduced by Polymerase Mutations Associated with Drug Resistance

Defective hepatitis B virus DNA (dDNA) is reverse-transcribed from spliced hepatitis B virus (HBV) pregenomic messenger RNA (pgRNA) and has been identified in patients with chronic HBV (CH-B). The major 2.2-kb spliced pgRNA encodes a novel HBV gene product, the hepatitis B splice protein (HBSP) via...

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Autors principals: Preiss, Scott, Littlejohn, Margaret, Angus, Peter, Thompson, Alex, Desmond, Paul, Lewin, Sharon R., Sasadeusz, Joe, Matthews, Gail, Dore, Gregory J., Shaw, Tim, Sozzi, Vitini, Yuen, Lilly, Lau, George, Ayres, Anna, Thio, Chloe, Avihingsanon, Anchalee, Ruxrungtham, Kiat, Locarnini, Stephen, Revill, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669111/
https://ncbi.nlm.nih.gov/pubmed/18571815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22386
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