α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

α-Tocopheryl succinate (α-TOS) is a selective inducer of apoptosis in cancer cells, which involves the accumulation of reactive oxygen species (ROS). The molecular target of α-TOS has not been identified. Here we show that α-TOS inhibits succinate dehydrogenase (SDH) activity of complex II (CII) by...

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Main Authors: Dong, Lan-Feng, Low, Pauline, Dyason, Jeffrey C., Wang, Xiu-Fang, Prochazka, Lubomir, Witting, Paul K., Freeman, Ruth, Swettenham, Emma, Valis, Karel, Liu, Ji, Zobalova, Renata, Turanek, Jaroslav, Spitz, Doug R., Domann, Frederick E., Scheffler, Immo E., Ralph, Stephen J., Neuzil, Jiri
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668987/
https://ncbi.nlm.nih.gov/pubmed/18372923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.69
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