In vitro Glutaminase Regulation and Mechanisms of Glutamate Generation in HIV-1 Infected Macrophage

Mononuclear phagocyte (MP, macrophages and microglia) dysfunction plays a significant role in the pathogenesis of HIV-1-associated dementia (HAD) through the production and release of soluble neurotoxic factors including glutamate. Glutamate production is greatly increased following HIV-1 infection...

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Main Authors: Erdmann, Nathan, Tian, Changhai, Huang, Yunlong, Zhao, Jianxing, Herek, Shelley, Curthoys, Norman, Zheng, Jialin
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668921/
https://ncbi.nlm.nih.gov/pubmed/19222703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2009.05989.x
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