Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study

In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4–6 weeks, followed by ivermectin (IVM) after 6 months. After 6–27 months, efficacy was evaluated by onchocercoma histology, PCR and microfilariae determination. Administration of doxyc...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hoerauf, Achim, Specht, Sabine, Büttner, Marcelle, Pfarr, Kenneth, Mand, Sabine, Fimmers, Rolf, Marfo-Debrekyei, Yeboah, Konadu, Peter, Debrah, Alexander Yaw, Bandi, Claudio, Brattig, Norbert, Albers, Anna, Larbi, John, Batsa, Linda, Adjei, Ohene, Büttner, Dietrich W.
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2007
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668626/
https://ncbi.nlm.nih.gov/pubmed/17999080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00430-007-0062-1
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