Preclinical Studies of Human Immunodeficiency Virus/AIDS Vaccines: Inverse Correlation between Avidity of Anti-Env Antibodies and Peak Postchallenge Viremia

A major challenge for human immunodeficiency virus (HIV)/AIDS vaccines is the elicitation of anti-Env antibodies (Ab) capable of neutralizing the diversity of isolates in the pandemic. Here, we show that high-avidity, but nonneutralizing, Abs can have an inverse correlation with peak postchallenge v...

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Библиографические подробности
Главные авторы: Zhao, Jun, Lai, Lilin, Amara, Rama Rao, Montefiori, David C., Villinger, Francois, Chennareddi, Lakshmi, Wyatt, Linda S., Moss, Bernard, Robinson, Harriet L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2009
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668498/
https://ncbi.nlm.nih.gov/pubmed/19224993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02173-08
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