The Epstein-Barr Virus (EBV) Deubiquitinating Enzyme BPLF1 Reduces EBV Ribonucleotide Reductase Activity

A newly discovered virally encoded deubiquitinating enzyme (DUB) is strictly conserved across the Herpesviridae. Epstein-Barr virus (EBV) BPLF1 encodes a tegument protein (3,149 amino acids) that exhibits deubiquitinating (DUB) activity that is lost upon mutation of the active-site cysteine. However...

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Autores principales: Whitehurst, Christopher B., Ning, Shunbin, Bentz, Gretchen L., Dufour, Florent, Gershburg, Edward, Shackelford, Julia, Langelier, Yves, Pagano, Joseph S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668490/
https://ncbi.nlm.nih.gov/pubmed/19244336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02195-08
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